Cough Science News
Find all editions of Cough Science News below and get access to the latest cough science developments, publications, and interviews with cough experts.
Find all editions of Cough Science News below and get access to the latest cough science developments, publications, and interviews with cough experts.
This month’s roundup explores placebo effects in RCC trials, the role of interoception in chronic cough, and the cost burden of persistent symptoms, plus insights from Dr. Nadia Giannetti.
New key cough science publications, Actigraph x Hyfe partnership and more
This year marked significant progress in cough monitoring, solidifying cough as a valuable biomarker in diverse therapeutic areas
New findings on refractory chronic cough (RCC), pulmonary tuberculosis, and pulmonary fibrosis. Plus latest white papers by Hyfe.
Cough Science News Oct 1 - new studies on cough-related stress urinary incontinence, COVID-19 detection in vaccinated adults, and the effectiveness of anti-reflux surgery for chronic cough. Plus, expert discussions from Hyfe's Cough Science Forum and the latest on FDA regulations for cough monitoring technologies
Cough Science News Oct 1 - new studies on cough-related stress urinary incontinence, COVID-19 detection in vaccinated adults, and the effectiveness of anti-reflux surgery for chronic cough. Plus, expert discussions from Hyfe's Cough Science Forum and the latest on FDA regulations for cough monitoring technologies
Cough Science News, August 2024 - Explore studies on cough variability, acute cough duration, and the cost burden of chronic cough. Plus, discover the world’s most comprehensive collection of cinematic coughs and upcoming events in cough science
CougH Science News July 2024 - latest in cough science. Insights on cough detection algorithms, pulmonary fibrosis, asthma diagnosis from cough sounds, and more. Plus, watch expert discussions and stay updated on upcoming events
Hyfe Cough Science News, June 2024. Latest research on cough in fibrotic ILD, high-dose inhaled corticosteroids for chronic cough, and family physicians’ approaches to managing chronic cough. Plus, insights from leading researchers and upcoming events
Cough Science News May 2024 - studies on cough monitoring for COVID-19 surveillance, the effectiveness of codeine for chronic cough, factors in refractory cough in IPF, and more. Plus, insights from researchers and upcoming events
Hyfe Cough Science News, March 2024 - insights on chronic cough management in the UK, common triggers in cough hypersensitivity, and a review of treatments for refractory cough. Plus, expert Q&A and upcoming cough science events.
Here’s What’s Inside
Key Takeaway: In IPF, studies have consistently reported correlations between various cough and HRQoL measures, with patients referencing disruption of daily activities, fatigue and social embarrassment. However the methods for assessing cough are heterogeneous, and there is minimal research into economic burden.
Why It Matters: The findings of this systematic research review confirm the negative impact of cough on HRQoL in IPF - it appears that cough is a symptom that, if better managed, can significantly improve patients’ lives. The study also highlights the need for standardized assessment tools for both objective cough and QoL.
Key Takeaway: 18 interviews & a survey with 298 ILD patients confirmed cough is one of the most bothersome symptoms of ILD, along with shortness of breath & fatigue. Half of patients thought a one-category change on a 5-option ordinal response scale would be meaningful for both worsening & improvement.
Why It Matters: The study suggests the potential for patient global impressions of severity (PGIS) as single-item PROs that can be used to understand what constitutes a meaningful change in symptoms for patients. With this measure, the minimum (i.e. 1-category) improvement or worsening of cough was considered meaningful.
Key Takeaways: This study used a novel PRO - the Sensations and Triggers Provoking Cough questionnaire (TOPIC) - and showed higher TOPIC scores in RCC patients versus other cough-related conditions. Median TOPIC score was significantly higher in RUCC (37.0) vs ILD (24.5, p=0.009) and asthma (7.0, p<0.001).
Why it matters: High TOPIC scores in RCC/UCC versus other diseases, suggests that RCC/UCC is characterised by specific sensations and triggers. The TOPIC questionnaire therefore may demonstrate value as an aid to diagnose RCC/UCC versus cough in other conditions
Exploring the Possibilities of Longitudinal Cough Data:
Q&A with Dr Emily Henkle, Associate Professor at Oregon Health & Science University
Dr Emily Henkle spoke to Hyfe about her research into PROs for Non-tuberculosis Mycobacteria (NTM). Her study includes analyzing cough patterns for their potential power to predict disease progression, plus assessing treatment impact.
“Our goal isn’t just to collect data for the sake of it, but to truly understand what’s useful to monitor, what can predict or expedite diagnosis, and when interventions are necessary”
