Research and Publications

53
Research Trials
20
Peer-reviewed publications
16
Clinical Conditions

$Image resource about POSTER: Digital Therapeutic For Refractory And Unexplained Chronic Cough: A Proof Of Concept Study$

PublicationsAbstracts

POSTER: Digital Therapeutic For Refractory And Unexplained Chronic Cough: A Proof Of Concept Study

At CHEST 2025, held in Chicago, Illinois, Laurie Slovarp, PhD, CCC-SLP, professor at the University of Montana and certified speech pathologist, presented a poster on the development of a digital therapeutic designed to improve access to behavioral cough suppression therapy for patients with refractory chronic cough.

21.10.2025

PublicationsPeer-reviewed

Azithromycin and oesophageal motility in chronic respiratory disease: a feasibility study

A large-scale trial examining the effect of azithromycin on the relationship between oesophageal function and cough as evaluated by Hyfe's cough monitoring technology in respiratory disease is feasible and acceptable to patients.

30.07.2025

PublicationsAbstracts

ATS 2025: ARINA-1 Improves Quality of Life in a Pilot Study of Chronic Bronchitis

This study used Hyfe's wearable cough monitor during a 7-day run in, 28-day treatment, and 14-day follow-up period in patients with chronic bronchitis.

14.05.2025

PublicationsAbstracts

ATS 2025: Evaluating Cough Bouts as a Metric for Cough Severity

Periods of intense coughing (termed bouts, epochs or bursts) are particularly problematic for some coughers and may not be reflected by simply counting the number of coughs per day. This study explored how varying the definition of bouts yield different impressions of cough severity.

14.05.2025

PublicationsAbstracts

ATS 2025: A Proof of Concept Therapeutic Solution for Chronic Cough: Personalized Monitoring and Targeted Suppression

The world’s first DTx for Refractory/Unexplained Chronic Cough (RCC/UCC). What it is? Digitally delivered behavioral cough suppression therapy (BCST), designed for high engagement to promote strong adherence. It includes continuous, passive cough monitoring and biofeedback loop enabling tailored personalization.

14.05.2025

PublicationsAbstracts

ATS 2025: Defining a 7-day Standard for Cough Monitoring: Data-driven Insights on Optimal Duration

A 7-day monitoring duration provides a robust, standardized timeframe for assessing cough frequency in clinical studies, offering a significant improvement over the traditional 24-hour period. This duration captures inter- and intra-individual cough variability.

14.05.2025

PublicationsPeer-reviewed

Validation and accuracy of the Hyfe cough monitoring system: a multicenter clinical study

This analysis of cough events demonstrated that the Hyfe CoughMonitor smartwatch, compared to a human listener, accurately detects coughs, with high sensitivity and a low false positive rate. Future studies should focus on its potential role in the management of patients with cough in clinical practice.

06.01.2025

PublicationsPeer-reviewed

A dataset of Solicited Cough Sound for Tuberculosis Triage Testing

The article presents a dataset of 733,756 cough sounds from 2,143 patients across 7 countries, accompanied by accurate demographic, clinical, and microbiological diagnostic annotations. It was collected using an early version of Hyfe’s research application, specifically designed to capture cough audio.

18.10.2024

$Image resource about Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency$

PublicationsPeer-reviewed

Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency

This is an exploratory, single-blind, nasal saline-controlled study involving 12 patients with refractory chronic cough, designed to examine the cough suppression efficacy of alkaline salts, monitored objectively with the previous version of the Hyfe CoughMonitor Suite.

08.10.2024

$Image resource about ERS 2024: Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency.$

PublicationsAbstracts

ERS 2024: Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency.

A single-blinded study in 12 chronic cough patients evaluated the cough-suppression efficacy of nasally delivered SC001 (pH 8 or 9) versus saline. Using Hyfe CoughMonitor, patients were monitored over three weeks. Results suggest alkaline (pH 9) SC001 aerosol shows promise for refractory chronic cough treatment.

01.10.2024

PublicationsAbstracts

ERS 2024: Is there a relationship between real-time continuous cough monitoring and subjective cough assessment?

A 30-day study of 12 chronic cough patients found no correlation between daily cough counts (median: 93/day) measured by the Hyfe CoughMonitor and symptom severity assessed via the Cough VAS. Further research is needed to identify better endpoints for evaluating chronic cough treatments.

01.10.2024

Image resource about ERS 2024: Longitudinal Cough Frequency Monitoring in Subjects with Persistent Cough: Daily Variability and Predictability Over 30 Days

PublicationsAbstracts

ERS 2024: Longitudinal Cough Frequency Monitoring in Subjects with Persistent Cough: Daily Variability and Predictability Over 30 Days

Coughing frequencies vary significantly between and within individuals, for those with a cough frequency of >5 coughs/h. One 24-hour measurement of cough does not reliably reflect long-term trends in up to half of those with persistent cough. This work provides methodological direction for subsequent definitive studies

01.10.2024

PublicationsAbstracts

ERS 2024: Validation and Accuracy of the Automated AI-powered Continuous Hyfe Cough Monitoring System

The Hyfe Cough Monitor System accurately monitors coughing in problematic coughers as they go about their usual daily activities. The ability to continually and passively monitor cough has the potential to improve patient care, cough research and drug development.

01.10.2024

Image resource about ERS 2024: Differentiating Cough Origins in Non-Contact AI Monitoring: Analyzing 'Non-User Coughs' with the Hyfe CoughMonitor Smartwatch

PublicationsAbstracts

ERS 2024: Differentiating Cough Origins in Non-Contact AI Monitoring: Analyzing 'Non-User Coughs' with the Hyfe CoughMonitor Smartwatch

This pilot work clarifies a methodology for quantifying this phenomenon and provides preliminary evidence that non-user coughs have a negligible effect on the cough estimates of the Hyfe Cough Monitor Watch in real-world settings.

01.10.2024

PublicationsPeer-reviewed

Continuous digital cough monitoring during 6-month pulmonary tuberculosis treatment

An earlier version of Hyfe’s cough monitoring technology was used to monitor cough for 6 months in this study with patients with pulmonary tuberculosis. Community-based continuous cough monitoring for pulmonary tuberculosis is feasible in low-resource settings.

19.09.2024

PublicationsPeer-reviewed

Longitudinal Cough Frequency Monitoring in Persistent Coughers: Daily Variability and Predictability

97 persistent coughers with at least 5 coughs/h were monitored for >20h a day for 30 days in real world environments using Hyfe - 2/3rds of them do not cough like metronomes

01.08.2024

PublicationsAbstracts

ATS 2024: Using Continuous Cough Monitoring to Assess Bronchiectasis Therapy

This is the first report demonstrating the feasibility of continual cough monitoring to assess the clinical impact of bronchiectasis therapy. The average rate of cough decreased significantly in all patients, suggesting that the airway clearance protocol at National Jewish is effective in rapidly reducing coughing.

22.05.2024

PublicationsAbstracts

ATS 2024: Validation of an Acoustic AI Cough Monitoring System

Over the 477 hours monitored, 4102 cough-seconds were recorded from the 20 subjects; the CoughMonitor detected 3715 of these (overall sensitivity 90.57%) and had 520 false positives (overall false positive rate of 1.09 false positives per hour).

22.05.2024

PublicationsAbstracts

ATS 2024: Cough-omics: Quantifying the Variability and Predictability of Daily Cough Countsin Persistent Coughers

Continuous passive cough monitoring demonstrates the heterogeneous and stochastic pattern of persistent cough and that 24 hour counts often inaccurately reflect longer term cough rates.

22.05.2024

PublicationsAbstracts

ATS 2024: Using Cough Sounds to Predict Chest Radiography Results

In this pilot study, we were able to collect coughs in the course of routine patient workflows and demonstrate that AI enabled algorithms are predictive of which individuals are likely to have an abnormal CXR.

22.05.2024

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