News & Updates
Interested in learning more about Hyfe? Read about all of our news, announcements and updates here!
Interested in learning more about Hyfe? Read about all of our news, announcements and updates here!
Comprehensive Chronic Cough Report reveals $15B opportunity. 100M patients, zero FDA-approved drugs, positioning digital cough monitoring as essential pharma infrastructure.
Review including Hyfe research evaluates continuous digital cough monitoring as a practical way to address limitations of patient-reported cough data
Study results demonstrate digital Behavioral Cough Suppression Therapy reduced cough frequency by over 40% in patients with refractory and unexplained chronic cough.
Strategic partnership with KYORIN Pharmaceuticals aims to improve outcomes and expand treatment access to millions impacted by chronic cough globally.
Hyfe’s AI-powered cough monitoring is now available on Actigraph’s FDA-cleared LEAP wearable, enabling continuous, privacy-preserving cough tracking alongside key health biomarkers
Clinical Trial Results Demonstrate Alkaline Magnesium-Based Salt Aerosol Reduced Cough Frequency by up to 35% in Refractory Chronic Cough Patients with Cough Counts Measured Continuously by AI-Powered tech
Hyfe's cough tracker was used in study by University of Navarra, revealing significant variability in cough patterns. This breakthrough highlights potential for continuous, objective chronic cough monitoring.
CoughPro app introduces the world’s first digital Cough Management feature, offering AI-driven solutions for millions suffering from chronic cough.
Research demonstrates the accuracy of Hyfe’s automated cough monitoring process and is the first to observe differences in type and length of cough between men and women.
AI company transitions app to subscription model and adds exclusive new features for users in the UK, Canada, Europe and global users outside the U.S.
Hyfe's technology integrated into ActiGraph’s new FDA-cleared LEAP wearable device that will advance the use of remote patient monitoring in chronic cough clinical research.
Studies show remote patient monitoring technology better predicts cough exacerbations to ultimately improve quality of life and reduce healthcare costs for patients with chronic cough.
Hyfe is expanding into chronic cough treatment with the world's first digital therapeutic for cough, using a proprietary model that combines real time cough frequency with cough suppression therapy.
150 winners selected out of 13,000 private companies; Hyfe recognized for contributions in screening, monitoring and diagnostics technologies
Hyfe has entered into an agreement with Merck, to integrate its artificial intelligence-powered (AI) cough tracker technology into Merck’s consumer disease educational efforts.
Leader in acoustic epidemiology empowers health care providers, researchers, pharmaceutical companies, and patients with cough detection and classification platform
Scientists use Hyfe to confirm that continuous cough monitoring for Long COVID was more sensitive in evaluating cough variability and response to treatment compared to patient reported outcomes.
Dr. Peter Small, Hyfe Chief Medical Officer has delivered deliver an intervention to the G20 Meeting in Yogyakarta, Indonesia, on the role of digital innovation in addressing public health crises.
With apps and artificial intelligence, researchers want to use the cough to better diagnose asthma, Covid-19 and other respiratory illnesses
Accomplished physician, scientist, and product developer to lead Hyfe's efforts as it seeks to transform patient care through cough monitoring and diagnosis.
Clinical Trial Results Demonstrate Alkaline Magnesium-Based Salt Aerosol Reduced Cough Frequency by up to 35% in Refractory Chronic Cough Patients with Cough Counts Measured Continuously by AI-Powered Detection Technology
BOSTON & SEATTLE - Sensory Cloud Inc., a health technology company pioneering treatments for respiratory human illnesses of the airway lining, and Hyfe Inc., a pioneer in AI-powered cough detection technology, announced promising results from an exploratory clinical study, published in ERJ Open Research, showing that Sensory Cloud’s investigational inhaled alkaline hypertonic divalent salt (HDS) aerosol significantly reduced cough frequency in patients suffering from refractory chronic cough (RCC). No clinically meaningful adverse events were reported. Cough counts were measured continuously using Hyfe Inc.’s AI-powered cough detection technology, RCC is a condition that is estimated to afflict approximately 10% of the human population, with limited treatment options.
Alkaline HDS aerosols, administered to the larynx from a simple spray-mist device, rehydrate the upper airways, potentially reducing neural inflammation, and lowering airway triggers of cough independently of cough-receptor category. In the clinical trial, initiated by Professor Kian Fan Chung at Imperial College London, RCC subjects wore a digital cough monitor watch (Hyfe Cough Monitor Suite) for 3 weeks, with one week of baseline cough monitoring, one week of saline control aerosol, and one week of treatment with an alkaline HDS aerosol (SC001). Placebo-adjusted efficacy of cough rate reduction ranged from 25% from Day 1 to 35% (p=0.02) from Day 3 for SC001 pH 9. No clinically meaningful adverse events were reported.
Treating RCC upstream of cough receptor provocation, rather than at a specific cough receptor target as the paradigm for most RCC drug candidates advancing in the clinic today, is an exciting potential new modality for RCC treatment. The results from this study across cough rates from 4 to 34 coughs per hour are encouraging, suggesting the possibility of a treatment for RCC, which patients we see at the Royal Brompton Clinic sorely need.
Professor Chung
Imperial College London
Dehydration of human upper airways worsens respiratory illnesses. The clinical trial results suggesting that cough frequency in RCC is reduced rapidly and across the entire range of cough rates with an endogenous rehydrating aerosol are encouraging for the potential of safely treating RCC, and possibly other chronic respiratory diseases provoked by dysfunction of the airway lining.
David A. Edwards
Former Harvard University professor and founder and CSO of Sensory Cloud Inc
We’re excited to see our technology play such a critical role in advancing the assessment of cough treatments. This study not only highlights the potential of Sensory Cloud’s alkaline HDS treatment but also demonstrates the transformative power of continuous cough monitoring in clinical trials.
Peter Small
Chief Medical Officer of Hyfe Inc
Alkaline HDS for treatment of RCC is now advancing in a Phase 2a clinical trial as an orally inhaled alkaline magnesium-chloride aerosol (SC0023). Cough counts will be monitored continuously for the 10 to 12 week duration of the trial by the Hyfe Cough Monitor Suite.
Sensory Cloud is a Boston-based biotechnology startup company pioneering aerosols that rehydrate human upper airways for prophylaxis against and treatment of respiratory illnesses triggered by mucosal inflammation. The Company’s proprietary HDS platform is an outcome of 20 years of scientific research at Harvard University and other leading research institutions in the US and internationally. Sensory Cloud is developing SC0023 as a first-line treatment for RCC.
Hyfe Inc. is a pioneer in AI-powered cough detection technology, providing continuous, passive monitoring solutions that offer real-time insights into respiratory health. Their technology is transforming the way respiratory conditions are diagnosed and managed.
Abubakar-Waziri H, Edwards DA, Bhatta DB, Hull JH, Rudd M, Small P, Chung KF. Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency. ERJ Open Res. 2024 Oct 7;10(5):00241-2024. doi: 10.1183/23120541.00241-2024. PMID: 39377090; PMCID: PMC11456969
For media inquiries please contact:
Sensory Cloud Inc. — info@sensory-cloud.com
Hyfe Inc. — press@hyfe.com
Comprehensive Chronic Cough Report reveals $15B opportunity. 100M patients, zero FDA-approved drugs, positioning digital cough monitoring as essential pharma infrastructure.
Review including Hyfe research evaluates continuous digital cough monitoring as a practical way to address limitations of patient-reported cough data
Study results demonstrate digital Behavioral Cough Suppression Therapy reduced cough frequency by over 40% in patients with refractory and unexplained chronic cough.
Strategic partnership with KYORIN Pharmaceuticals aims to improve outcomes and expand treatment access to millions impacted by chronic cough globally.