53
Research Trials
20
Peer-reviewed publications
16
Clinical Conditions
Hyfe pilot study tests a digital therapeutic combining passive cough monitoring with behavioral suppression techniques delivered through the CoughPro app.
This narrative review by Hyfe's R&D team makes the case that continuous cough monitoring (CCM), powered by acoustic AI, transforms cough from a subjective symptom into a quantifiable digital biomarker.
Independent ERS 2025 NeuroCOUGH trial uses the Hyfe Cough Tracker to test feasibility of studying azithromycin's effect on cough and oesophageal motility.
Independent ERS 2025 trial uses the Hyfe Cough Tracker to show azithromycin reduces objective cough frequency by week one in chronic respiratory disease.
The Hyfe “CoughMonitor” is a wrist-worn device thatcaptures sound through its microphone and processesthat sound on device to detect and quantify coughingover time; the device ingests continuous audio andoutputs the timestamps of all of the coughs that itdetects. To assess the CoughMonitor’s accuracy, onemust compare its output (when the device reportsthat coughing occurred) with objective ground truth(when trained human annotators report that coughingoccurred).
A perfectly accurate device would detectevery human annotated cough as such and would notidentify anything else as a cough.This paper describes a small pilot study aimed atquantifying the accuracy of an earlier version of theHyfe CoughMonitor and, in so doing, demonstrates theanalytical approach and data presentation that will beemployed in the subsequent FDA enabling study.
