53
Research Trials
20
Peer-reviewed publications
16
Clinical Conditions
Hyfe pilot study tests a digital therapeutic combining passive cough monitoring with behavioral suppression techniques delivered through the CoughPro app.
This narrative review by Hyfe's R&D team makes the case that continuous cough monitoring (CCM), powered by acoustic AI, transforms cough from a subjective symptom into a quantifiable digital biomarker.
Independent ERS 2025 NeuroCOUGH trial uses the Hyfe Cough Tracker to test feasibility of studying azithromycin's effect on cough and oesophageal motility.
18 November 2025
This investigator-led feasibility trial from the NeuroCOUGH Clinical Research Collaboration tested whether a definitive study of azithromycin's effect on cough and oesophageal motility in chronic respiratory disease is achievable, pairing continuous cough monitoring with repeated high-resolution oesophageal manometry (HROM). Thirty patients with chronic cough and established respiratory disease were monitored continuously for one week before and four weeks during open-label azithromycin 250 mg daily using the Hyfe Cough Tracker, with HROM performed at baseline and at four weeks. Recruitment hit three patients per month at a single centre, 87% completed all visits, and every pre-specified data quality outcome met its stop-go criterion. Notably, 52% of patients had abnormal oesophageal function at baseline, and among those who underwent repeat HROM, 42% showed greater than 30% improvement in distal contractile integral after treatment. The findings establish feasibility for a definitive trial examining the gut-lung axis in respiratory disease and identify DCI as a viable outcome measure.
