53
Research Trials
20
Peer-reviewed publications
16
Clinical Conditions
Hyfe pilot study tests a digital therapeutic combining passive cough monitoring with behavioral suppression techniques delivered through the CoughPro app.
This narrative review by Hyfe's R&D team makes the case that continuous cough monitoring (CCM), powered by acoustic AI, transforms cough from a subjective symptom into a quantifiable digital biomarker.
Independent ERS 2025 NeuroCOUGH trial uses the Hyfe Cough Tracker to test feasibility of studying azithromycin's effect on cough and oesophageal motility.
Independent ERS 2025 trial uses the Hyfe Cough Tracker to show azithromycin reduces objective cough frequency by week one in chronic respiratory disease.
Authored by Hyfe's R&D team, this review synthesizes work presented at the European Respiratory Society Congress 2025 and argues that objective cough monitoring has crossed a practical threshold, moving from experimental technique to deployable clinical endpoint.
Validated algorithms across smartwatches, chest patches, pendants, and audio recorders now show strong agreement with human annotation (sensitivities of 90 to 97%) across refractory chronic cough, COPD, IPF, ILD, and asthma. The review also covers convergence on a 7-day monitoring standard, device-verified adherence at scale, and early efficacy and tolerability signals from interventional trials using continuous cough endpoints. The authors conclude that cough is transitioning from a background symptom to a quantifiable data stream ready to support precision respiratory care across therapeutic areas.
