53
Research Trials
20
Peer-reviewed publications
16
Clinical Conditions
Hyfe pilot study tests a digital therapeutic combining passive cough monitoring with behavioral suppression techniques delivered through the CoughPro app.
This narrative review by Hyfe's R&D team makes the case that continuous cough monitoring (CCM), powered by acoustic AI, transforms cough from a subjective symptom into a quantifiable digital biomarker.
Independent ERS 2025 NeuroCOUGH trial uses the Hyfe Cough Tracker to test feasibility of studying azithromycin's effect on cough and oesophageal motility.
Independent ERS 2025 trial uses the Hyfe Cough Tracker to show azithromycin reduces objective cough frequency by week one in chronic respiratory disease.
18.11.2025
Continuous cough monitoring is only as useful as the time a participant actually wears the device, making objective adherence measurement a prerequisite for trustworthy trial endpoints. This ERS 2025 abstract from Hyfe's R&D team validates the wear-detection algorithm built into the Hyfe CoughMonitor smartwatch against participant-reported wear status across 418 person-hours of data in ten participants. Applying the established Choi accelerometer algorithm, the system classified wear versus non-wear with 94.6% sensitivity and 93.8% specificity, with a positive predictive value for non-wear of 95.5% and a negative predictive value for wear of 92.5%. The CoughMonitor Suite dashboard surfaced these adherence signals in real time, giving study teams a device-verified alternative to self-report. The findings support the smartwatch's use in clinical trials where objective cough dynamics depend on knowing, with confidence, when the device was actually being worn.
