Research and Publications

62
Research Trials
22
Peer-reviewed publications
17
Clinical Conditions

Image resource about A Prospective Decentralized Pilot Study Assessing a Digital Therapeutic Feature Inside CoughPro: For Adults with RCC/UCC

A Prospective Decentralized Pilot Study Assessing a Digital Therapeutic Feature Inside CoughPro: For Adults with RCC/UCC

Hyfe pilot study tests a digital therapeutic combining passive cough monitoring with behavioral suppression techniques delivered through the CoughPro app.

4 December 2025

PublicationsPeer-reviewed

The value of continuous cough monitoring: a narrative review

This narrative review by Hyfe's R&D team makes the case that continuous cough monitoring (CCM), powered by acoustic AI, transforms cough from a subjective symptom into a quantifiable digital biomarker.

30 November 2025

PublicationsAbstracts

Azithromycin and continuous cough monitoring: an open-label trial

Independent ERS 2025 trial uses the Hyfe Cough Tracker to show azithromycin reduces objective cough frequency by week one in chronic respiratory disease.

18 November 2025

PublicationsAbstracts

Optimizing Cough Frequency Assessment: A 7-Day Monitoring Standard

Hyfe ERS 2025 abstract presents evidence for a 7-day cough monitoring standard, replacing 24-hour windows long used in respiratory clinical research.

18 November 2025

PublicationsAbstracts

Objective Assessment of Adherence in Continuous Cough Monitoring: Wear Detection on the Hyfe CoughMonitor Smartwatch

This ERS 2025 abstract from Hyfe's R&D team validates the wear-detection algorithm built into the Hyfe CoughMonitor smartwatch against participant-reported wear status across 418 person-hours of data in ten participants.

18 November 2025

PublicationsAbstracts

Azithromycin and Oesophageal Motility in Chronic Respiratory Disease: A Feasibility Trial

Independent ERS 2025 NeuroCOUGH trial uses the Hyfe Cough Tracker to test feasibility of studying azithromycin's effect on cough and oesophageal motility.

18 November 2025

Image resource about Continuous cough monitoring to evaluate tolerance to inhaled antibiotic treatment in patients with chronic bronchial infection

PublicationsAbstracts

Continuous cough monitoring to evaluate tolerance to inhaled antibiotic treatment in patients with chronic bronchial infection

Independent ERS 2025 pilot uses the Hyfe Cough Monitoring System to track inhaled antibiotic tolerance in bronchiectasis, flagging adverse responses early.

18 November 2025

PublicationsResearch memos

Counting Coughs: ERS 2025 Highlights on Objective Cough Monitoring

Authored by Hyfe's R&D team, this review synthesizes work presented at the European Respiratory Society Congress 2025 and argues that objective cough monitoring has crossed a practical threshold, moving from experimental technique to deployable clinical endpoint.

11 November 2025

$Image resource about POSTER: Digital Therapeutic For Refractory And Unexplained Chronic Cough: A Proof Of Concept Study$

PublicationsAbstracts

POSTER: Digital Therapeutic For Refractory And Unexplained Chronic Cough: A Proof Of Concept Study

At CHEST 2025, held in Chicago, Illinois, Laurie Slovarp, PhD, CCC-SLP, professor at the University of Montana and certified speech pathologist, presented a poster on the development of a digital therapeutic designed to improve access to behavioral cough suppression therapy for patients with refractory chronic cough.

21 October 2025

$Image resource about Digital Therapeutic for Refractory and Unexplained Chronic Cough: A Proof of Concept Study$

PublicationsAbstracts

Digital Therapeutic for Refractory and Unexplained Chronic Cough: A Proof of Concept Study

This study asked whether the core components of BCST could be embedded in a digital therapeutic and paired with continuous, objective cough monitoring inside the CoughPro app.

21 October 2025

$Image resource about Internet-Based Behavioral Cough Suppression Therapy for Refractory Chronic Cough: A Randomized Controlled Trial$

PublicationsPeer-reviewed

Internet-Based Behavioral Cough Suppression Therapy for Refractory Chronic Cough: A Randomized Controlled Trial

This randomized controlled trial tested whether behavioral cough suppression therapy, a treatment that normally requires in-person visits with a specialized speech-language pathologist, could be delivered entirely online.

4 September 2025

PublicationsPeer-reviewed

Azithromycin and oesophageal motility in chronic respiratory disease: a feasibility study

A large-scale trial examining the effect of azithromycin on the relationship between oesophageal function and cough as evaluated by Hyfe's cough monitoring technology in respiratory disease is feasible and acceptable to patients.

30 July 2025

PublicationsAbstracts

ATS 2025: Defining a 7-day Standard for Cough Monitoring: Data-driven Insights on Optimal Duration

A 7-day monitoring duration provides a robust, standardized timeframe for assessing cough frequency in clinical studies, offering a significant improvement over the traditional 24-hour period. This duration captures inter- and intra-individual cough variability.

14 May 2025

PublicationsAbstracts

ATS 2025: A Proof of Concept Therapeutic Solution for Chronic Cough: Personalized Monitoring and Targeted Suppression

The world’s first DTx for Refractory/Unexplained Chronic Cough (RCC/UCC). What it is? Digitally delivered behavioral cough suppression therapy (BCST), designed for high engagement to promote strong adherence. It includes continuous, passive cough monitoring and biofeedback loop enabling tailored personalization.

14 May 2025

PublicationsAbstracts

ATS 2025: ARINA-1 Improves Quality of Life in a Pilot Study of Chronic Bronchitis

This study used Hyfe's wearable cough monitor during a 7-day run in, 28-day treatment, and 14-day follow-up period in patients with chronic bronchitis.

14 May 2025

PublicationsAbstracts

ATS 2025: Evaluating Cough Bouts as a Metric for Cough Severity

Periods of intense coughing (termed bouts, epochs or bursts) are particularly problematic for some coughers and may not be reflected by simply counting the number of coughs per day. This study explored how varying the definition of bouts yield different impressions of cough severity.

14 May 2025

PublicationsPeer-reviewed

Validation and accuracy of the Hyfe cough monitoring system: a multicenter clinical study

This analysis of cough events demonstrated that the Hyfe CoughMonitor smartwatch, compared to a human listener, accurately detects coughs, with high sensitivity and a low false positive rate. Future studies should focus on its potential role in the management of patients with cough in clinical practice.

6 January 2025

PublicationsPeer-reviewed

A dataset of Solicited Cough Sound for Tuberculosis Triage Testing

The article presents a dataset of 733,756 cough sounds from 2,143 patients across 7 countries, accompanied by accurate demographic, clinical, and microbiological diagnostic annotations. It was collected using an early version of Hyfe’s research application, specifically designed to capture cough audio.

18 October 2024

$Image resource about Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency$

PublicationsPeer-reviewed

Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency

This is an exploratory, single-blind, nasal saline-controlled study involving 12 patients with refractory chronic cough, designed to examine the cough suppression efficacy of alkaline salts, monitored objectively with the previous version of the Hyfe CoughMonitor Suite.

8 October 2024

Image resource about ERS 2024: Longitudinal Cough Frequency Monitoring in Subjects with Persistent Cough: Daily Variability and Predictability Over 30 Days

PublicationsAbstracts

ERS 2024: Longitudinal Cough Frequency Monitoring in Subjects with Persistent Cough: Daily Variability and Predictability Over 30 Days

Coughing frequencies vary significantly between and within individuals, for those with a cough frequency of >5 coughs/h. One 24-hour measurement of cough does not reliably reflect long-term trends in up to half of those with persistent cough. This work provides methodological direction for subsequent definitive studies

1 October 2024

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